郭子建

基本简介

教授、博士生导师。1989-1994年在意大利帕多瓦大学并获得博士学位。曾在英国伦敦大学、加拿大不列颠哥伦比亚大学、英国爱丁堡大学从事研究工作，研究方向为抗肿瘤金属配合物的作用机理研究。1999年起担任南京大学教授、博士生导师。2002年被评为享受国务院特殊津贴专家，2017年当选中国科学院化学部院士。目前担任Chem. Soc. Rev., Inorg. Chem., Dalton Trans., J. Biol. Inorg. Chem., J. Inorg. Biochem.等国际期刊的编委以及《中国科学：化学》等多个国内刊物的编委或副主编。主要研究领域为生物无机化学，研究方向包括：无机药物化学、金属-生物大分子相互作用机制以及生物无机物种的荧光识别与检测。

研究方向：生物无机化学，生物材料化学，尤其是金属药物化学的研究工作：包括新型含铂、含钌、含铜抗癌配合物的设计及作用机理研究；金属药物的包裹与控制释放；金属-生物大分子的相互作用及溶液结构研究；金属自由基清除剂。

发表论文

1. X. Zhao, N. Yeung, Z.L. Wang, Z.J. Guo, Y. Lu, Effects of Metal Ions in the Cu-B Center on the Redox Properties of Heme in Heme-Copper Oxidases: Spectroelectrochemical Studies of an Engineered Heme-Copper Center in Myoglobin, Biochemistry, 2005, 44, 1210.

2. J. Hong, Y. Miao, R. Miao, G.S. Yang, H.W. Tang, Z.J. Guo, L.G. Zhu, Binding Sites of [Ru(bpy)2(H2O)2](BF4)2 with Sulfur- and Histidine-containing Peptides Studied by Electrospray Ionization Mass Spectrometry and Tandem Mass Spectroscopy, J. Mass Spectrom., 2005, 40, 91. 2004

3. S.C. Zhang, Y.G. Zhu, C. Tu, H.Y. Wei, Z. Yang, L.P. Lin, J. Ding, J.F. Zhang, Z.J. Guo, A Novel Cytotoxic Ternary Copper(II) Complex of 1,10-Phenanthroline and L-Threonine with DNA Nuclease Activity, J. Inorg. Biochem., 2004, 98, 2099.

4. S.C. Zhang, C. Tu, X.Y. Wang, Z. Yang, J.Y. Zhang, L.P. Lin, J. Ding, Z.J. Guo, Novel Cytotoxic Copper(II) Complexes of 8-Aminoquinoline Derivatives: Crystal Structure and Different Reactivity towards Glutathione, Eur. J. Inorg. Chem., 2004, 4028.

5. J. R. Carey, S. K. Ma, T. D. Pfister, D. K. Garner, H. K. Kim, J.A. Abramite, Z.L. Wang, Z.J. Guo, Y. Lu, A Site-Selective Dual Anchoring Strategy for Artificial Metalloprotein Design, J. Am. Chem. Soc., 2004, 126, 10812.

6. C. Tu, Y. Shao, N. Gan, Q. Xu, Z.J. Guo, Oxidative DNA Strand Scission Induced by a Trinuclear Copper(II) Complex, Inorg. Chem., 2004, 43, 4761.

7. H.Y. Wei, Q. Liu, J. Lin, P.J. Jiang, Z.J. Guo, Fast displacement of S,N-chelated L-methionine in platinum(II) complexes by biological thiols, Inorg. Chem. Commun., 2004, 7, 792.

8. X.J. Sun, C. Jin, Y.H. Mei, G.S. Yang, Z.J. Guo, L.G. Zhu, Interaction of palladium(II) and platinum(II) complexes with microperoxidase-11 studied by electrospray mass spectrometry and MS/MS analysis, Inorg. Chem., 2004, 43, 290.

9. P.J. Jiang and Z.J. Guo, Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors, Coord. Chem. Rev., 2004, 248, 205.

10. Q. Liu, H.Y. Wei, J. Lin, L.G. Zhu and Z.J. Guo, Novel polynuclear platinum adducts detected during the reactions of [Pt(Met-S,N)Cl2] with g-glutathione and L-cysteine, J. Inorg. Biochem., 2004, 98, 702.

11. C. Tu, X.F. Wu, Q. Liu, X.Y. Wang, Q. Xu and Z.J. Guo, Crystal structure, DNA-binding ability and cytotoxic activity3 of platinum(II) 2,20-dipyridylamine complexes, Inorg. Chem. Acta, 2004, 357, 95. 2003

12. C. Tu, J. Lin, Y. Shao, Z.J. Guo, Toward the Design of Novel Polynuclear Platinum Antitumor Complexes: A Polydentate Ligand System Based on Dipyridylamine and 1,3,5-Trimethylenebenzene, Inorg. Chem., 2003, 42, 5796.

13. T. Yang, C. Tu, J.Y. Zhang, L.P. Lin, X.M. Zhang, Q. Liu, J. Ding, Q. Xu, Z.J. Guo, Novel Au(III) complexes of Aminoquinoline Derivatives: Crystal Structure, DNA Binding and Cytotoxicity Against Melanoma and Lung Tumor cells, Dalton Trans., 2003, 3419.

14. X.Y. Wang, X.M. Zhang, J. Lin, J.W. Chen, Q. Xu, Z.J. Guo, DNA-Binding Property and Antitumor Activity of Bismuth(III) Complex with 1, 4, 7, 10-Tetrakis(2-pyridylmethyl)-1, 4, 7, 10- tetraazacyclododecane, Dalton Trans., 2003, 2379.

15. J.Y. Zhang, X.Y. Wang, C. Tu, J. Lin, J. Ding, L.P. Lin, Z.M. Wang, C. He, C.H. Yan, X.Z. You, Z.J. Guo, Monofunctional Platinum Complexes Showing Potent Cytotoxicity Against Human Liver Carcinoma Cell Line BEL-7402, J. Med. Chem., 2003, 46, 3502.

16. X.J. Sun, L. Zhang, Y. Zhang, G.S. Yang, Z.J. Guo, L.G. Zhu, New insights into the palladium-mediated selective hydrolysis of the His18-Thr19 peptide bond in cytochrome c: 1H NMR and density functional theory investigated for model compounds, New J. Chem., 2003, 27, 818.

17. X.Y. Wang, J. Lin, X.M. Zhang, Q. Liu, Q. Xu, R.X. Tan, Z.J. Guo, 5-fluorouracil-cisplatin adducts with potential antitumor activity, J. Inorg. Biochem., 2003, 94, 186.

18. J.Y. Zhang, X.K. Ke, C. Tu, J. Lin, J. Ding, L.P. Lin, H.K. Fun, X.Y. You, Z.J. Guo, Novel Cu(II)-quinoline carboxamide complexes: Structural characterization, cytotoxicity and reactivity towards 5 -GMP, Biometals, 2003, 16, 485.

19. J. Lin, C. Tu, H. Lin, P.J. Jiang, J. Ding, Z.J. Guo, Crystal structure and superoxide dismutase activity of a six-coordinate manganese(III) complex, Inorg. Chem. Commun., 2003, 6, 262. 2002

20. R. Morris, A. Habtemariam, Z.J. Guo, S. Parsons and P.J. Sadler, Chelate ring-opening aminophosphine complexes of ruthenium(II), Inorg. Chim. Acta, 2002, 339, 551.

21. L. Zhang, H. Wei, Y. Zhang, Z.J. Guo and L.G. Zhu, Theoretical Study of Far-Infrared Spectra of Some Palladium and Platinum Halide Complexes, J. Phys. Chem. A, 2002, 106, 3819.

22. L. Zhang, Y. Zhang, H.B. Tao, X.J. Sun, Z.J. Guo and L.G. Zhu, Investigation of Calix[4]arene-porphyrin and its Palladium(II) and Zinc(II) Complexes at air/water Interface and in langmuir-Blodgett Film, Thin Solid Films, 2002, 413, 224.

23. W.J. He, C.Y. Jiang, F. Liu, Z.H. Tai, Y.Q. Liang, Z.J. Guo and L.G. Zhu, Monolayer Formation of Alkyl Chain-Containing Phosphoric Acid Amphilphiles at the Air/Water )pH 5.6) Interface: Influence of Temperature and Cations, J. Colloid Interface Sci., 2002, 246, 335.

24. Y. Xu, B.L. Li, H.B. Liu, Z.J. Guo, Z.H. Tai and Z. Xu, Liquid Crystalline Thiadiazole Derivatives: New Ferroelectric Thiadiazole Derivatives, Liquid Crystals, 2002, 29, 199.

25. D.R. Zhu, Y. Xu, Z. Yu, Z.J. Guo, H. Sang, T. Liu and X.Y. You, A Novel Bis(trans-thiocyanate)iron(II) Spin-Transition Molecular Material with Bidentate Triaryltriazole Ligands and its Bis(cis-thiocyanate)iron(II) Hign-Spin Isomer, Chem. Mater., 2002, 14, 838.

26. Q. Liu, J. Lin, P.J. Jiang, J.Y. Zhang, L.G. Zhu, Z.J. Guo, Monitoring the Reactions of the Anticancer Drug Carboplatin with the Chemopreventive Agent Selenomethionine by Electrospray Mass Spectrometry and [1H,15N] HSQC NMR Spectroscopy, Eur. J. Inorg. Chem., 2002, 2170.

27. Z.J. Guo, W.Q. Zhong and P.J. Sadler, Metals in the Brain, Edu. Chem., 2002, 68.

28. P.J. Jiang, L.Z Chen, J. Lin, Q. Liu, X. Gao and Z.J. Guo, Novel Zinc Fluorescent Probe Bearing Dansyl and Aminoquinoline Groups, Chem. Commun., 2002, 1424- 1425.

29. J.Y. Zhang, Q. Liu, C.Y. Duan, Y. Shao, J. Ding, Z.H. Miao, X.-Z. You and Z.J. Guo, Structural Evidence for the Facile Chelate-Ring Opening Reactions of Novel Platinum(II)-Pyridine Carboxamide Complexes, J. Chem. Soc., Dalton Trans., 2002, 591. 2001

30. M.L. Guo, Z.J. Guo and P.J. Sadler, Titanium(IV) Targets Phosphoesters on Nucleotides: Implications for the mechanism of Action of the Anticancer Drug Titanocene Dicholride, J. Biol. Inorg. Chem., 2001, 6, 698-707.

31. W.J. He, F. Liu, Y.H. Mei, Z.J. Guo and L.G. Zhu, Synthesis and Electrospray Mass Spectrometry Study of Pd(II) Complexes of Low-rim Amino Acid Substituted Calix[4]arenes, New. J. Chem., 2001, 25, 1330-1336.

32. W.J. He, F. Liu, C.Y. Duan, Z.J. Guo, S.Z. Zhou, Y.J. Liu and L.G. Zhu, Construction of a Square-Planar Molecular Box: Self-Assembly of Palladium(II) Complexes of 3,6,9,19,22-Hexaazatricyclo[22.2.2.211,14]triacon-11,13,24,26(1), 27,29-hexaene through Hydrogen-Bonding Interactions, Inorg. Chem., 2001, 40, 7065-7071.

33. Y. Zhang, Z.J. Guo and X.Z. You, The hydrolysis theory for cisplatin and its analogues based on density functional studies, J. Am. Chem. Soc., 2001, 123, 9378-9387.

34. Y. Xu, D.R. Zhu, Z.J. Guo, Y.J. Shi, K.L. Zhang and X.Z. You, Cation-induced assembly of the first mixed molybdenum vanadium hexadecametal host shell cluster anions, J. Chem. Soc., Dalton Trans., 2001, 772-773.

35. R.X. Yuan, R.G. Xiong, Z.F. Chen, P. Zhang, H.X. Ju, Z.J. Guo, H.K. Fun and X.Z. You, Crystal structure of zinc(II) 2-sulfanilamidopyrimidine: a widely used topical burn drug, J. Chem. Soc., Dalton Trans., 2001, 776-778.

36. Q. Liu, J.Y. Zhang, X.K. Ke, Y.H. Mei, L.G. Zhu and Z.J. Guo, ESMS and NMR investigations on the interaction of the anticancer drug cisplatin and chemopreventive agent selenomethionine, J. Chem. Soc., Dalton Trans., 2001, 911-916.

37. W.J. He, F. Liu, Z. F. Ye, Y. Zhang, Z.J. Guo, and L.G. Zhu, X. H. Zhai and J. B. Li, Monolayers of Novel Calix[4]arene Derivative and Its Palladium(II) Complexes Formed at the Air-Water Interface, Langmuir, 2001, 17, 1143 – 1149. 2000

38. H. Wei, X.M. Luo, Y.B. Wu, Y. Yao, Z.J. Guo and L.G. Zhu, Compositions and conformations of several transition metal complexes with a nonapeptide hormone oxytocin, J. Chem. Soc., Dalton Trans., 2000, 4196-4200.

39. Z.-F. Chen, R.-G. Xiong, J.-L. Zuo, Z.J. Guo, X.-Z. You, H.-K. Fun, X-Ray Crystal structures of Mg2+ and Ca2+ dimers of the antibacterial drug norfloxacin, J. Chem. Soc., Dalton Trans., 2000, 4013-4014.

40. X.M. Luo, W.J. He, Y. Zhang, Z.J. Guo and L.G. Zhu, Pd(II) complexes mediated hydrolytic cleavage of insulin B chain: regioselectivity and influence of peptide secondary structure, Chem. Lett., 2000, 1030-1031.

41. J.A. Parkinson, Y. Chen, P.D. Murdoch, Z.J. Guo, S.J. Berners-Price, T. Brown and P.J. Sadler, Sequence-dependent bending of DNA induced by cisplatin: NMR structures of an AT-rich 14-mer duplex, Chem. Eur. J., 2000, 6, 3636-3644. 1999

42. Y. Chen., J.A. Parkinson, Z.J. Guo, T. Brown and P.J. Sadler, A New Platinum Anticancer Drug Forms a Highly Stereoselective Adducts with Duplex DNA, Angew. Chem. Int. Ed. Engl. 1999, 38, 2060-2063.

43. J. Zou, Z.J. Guo, J.A. Parkinson, Y. Chen and P.J. Sadler, Gold-induced Oxidation of Glycine, Chem. Commun. 1999, 1359-1360.

44. Z. J. Guo and P.J. Sadler, Medicinal Inorganic Chemistry, Advances Inorg. Chem., 2000, 49, 183-306.

45. S.L. Best, Z.J. Guo, M.I. Djuran and P.J. Sadler, [Au(III)(dien)Cl]Cl2: Exchange Phenomena Observed by 1H and 13C NMR Spectroscopy, Metal-Based Drugs, 1999, 6, 261-269.

46. P.J. Sadler and Z.J. Guo, Inorganic Chemistry and Medicine, Chem. Austr., 1999, 66, 6-13.

47. Z.J. Guo and P.J. Sadler, Metals in Medicine, Angew. Chem. Int. Ed. Engl., 1999, 38, 1512-1531. 1998

48. Y. Chen, Z.J. Guo, J.A. Parkinson and P. J. Sadler, Kinetic Control of Reactions of Sterically-hindered Platinum Picoline Anticancer Complex with Guanosine 5 -monophosphate and Glutathione, J. Chem. Soc., Dalton Trans., 1998, 3577- 3585.

49. P. del S. Murdoch, Z.J. Guo, J.A. Parkinson and P.J. Sadler, Kinetics of Formation and Stability of {Pt(dien)}2+ Complexes with Octamer and 14-mer DNA Oligonucleotides Containing a GG Sequence, J. Biol. Inorg. Chem., 1999, 4, 32-38.

50. A.R. Brown, Z.J. Guo, F.W.J. Mosselmans, S. Parsons. M. Schroder and L.J. Yellowless, Structural and Voltammetric Studies on the Reduction of the Bis(2,2 -bipyridyl)platinum(II) Cation in Aprotic Media, J. Am. Chem. Soc., 1998, 120, 8805-8811.

51. N.A. Kratochwil, Z.J. Guo, P. del S. Murdoch, P. J. Bednarski and P.J. Sadler, Electron-transfer-driven Trans-Ligand Labilization: A Novel Activation Mechanism for Pt(IV) Anticancer Complexes, J. Am. Chem. Soc., 1998, 120, 8253-8254.

52. P.J. Sadler and Z.J. Guo, Metal Complexes in Medicine: Design and Mechanism of Action, Pure Appl. Chem., 1998, 70, 863-871.

53. Z. Guo, A. Habtemariam, P.J. Sadler and B.R. James, Chelate Ring-opening Ruthenium Complexes: X-ray Crystal Structure and Solution Studies of cis, trans-Bis-(2-dimethyl-aminoethyl)diphenyl-phosphino(dichloro)ruthenium(II), Inorg. Chim. Acta, 1998, 273, 1-7.

54. Z.J. Guo, P.J. Sadler and S.C. Tsang, Immobilization and Visualization of DNA and Proteins on Carbon Nanotubes, Adv. Mater. 1998, 10, 701-703.

55. Y. Chen, Z.J. Guo, S. Parsons and P.J. Sadler, Stereospecific and Kinetic Control over Hydrolysis of a Sterically-Hindered Platinum Picoline Anticancer Complex, Chem. Eur. J., 1998, 4, 672-676.

56. Y. Chen, Z.J. Guo, P. del S. Murdoch, E. Zang and P.J. Sadler, Interconversion between S- and N-bound L-Methionine Adducts of Pt(dien)2+ (dien = diethylenetriamine) via dien Ring-opened Intermediates, J. Chem. Soc., Dalton trans., 1998, 1503-1508.

57. Z.J. Guo, A, Habtemariam, P.J. Sadler, R. Palmer and B.S. Potter, Conformational Flexibility within the Chelate Rings of [Pt(en)(CBDCA-O,O )] - an Analogue of the Antitumour Drug Carboplatin: X-ray Crystallographic and Solid-State NMR Studies, New J. Chem., 1998, 11-14. 1997

58. Z.J. Guo, Y. Chen, E. Zang and P.J. Sadler, [1H,15N] NMR Studies of [Pt(dien)Cl]+: Hydrolysis and Reactions with Nucleotides, J. Chem. Soc., Dalton Trans., 1997, 4107-4111.

59. F. Reeder, Z.J. Guo, S. del P. Murdoch, A. Corazza, T.W. Hambley, S.J. Berners-Price, J.-C. Chottard and P.J. Sadler, Platination of a GG Single- and Double-stranded 14mer Oligonucleotide by Cisplatin Diaqua Followed by NMR and HPLC. Influence of the Platinum Ligands and Base Sequence on 5 -G versus 3 -G Platination Selectivity, Eur. J. Biochem., 1997, 249, 370-382.

60. S.C. Tsang, Z.J. Guo, Y.K. Chen, M.L.H. Green, H.A.O. Hill, T.W. Hambley and P.J. Sadler, Immobilization of Platinated and Iodinated DNA Oligomers on Carbon Nanotubes, Angew. Chem. Int. Ed. Engl., 1997, 36, 2198-2200.

61. S.J. Berners-Price, A. Corazza, Z.J. Guo, K.J. Barnham, P.J. Sadler, M. Leng and D. Locker, Structural Transitions of a GG-Platinated DNA Duplex Induced by pH, Temperature and HMG1 Box A, Eur. J. Biochem., 1997, 243, 782-791.

62. Z.J. Guo, T. W. Hambly, P. del S. Murdoch and P. J. Sadler, Chelate-ring-opened Adducts of [Pt(en)(2-methylmalonate-O,O′)] with Methionine Derivatives: Relevance to the Biological Activity of Platinum Anticancer Agents, J. Chem. Soc., Dalton Trans., 1997, 469-478.

63. Z.J. Guo, P.J. Sadler, E. Zang, Recognition of Pt(II) Amine Complexes by Nucleotides: Role of Phosphate and Carbonyl Groups in [Pt(15N-diethylenetriamine)(guanosine 5′-monophosphate)]2+, Chem. Commun., 1997, 27-28. 1996

64. K. J. Barnham, Z.J. Guo and P. J. Sadler, Stabilization of Monofunctional Platinum-Nucleotide Adducts: Reactions of Acetyl-L-Methionine Complexes with Guanosine 5′-Monophosphate and Guanylyl(3′-5′)Guanosine, J. Chem. Soc., Dalton Trans., 1996, 2867-2876. 1995

65. Z.J. Guo, G. Faraglia and S. Sitran, Palladium and Platinum Complexes with N-Substituted Methionines, Transition Met. Chem., 1995, 20, 91-96.

66. Z.J. Guo, K.J. Barnham and P. J. Sadler, DNA platination via S-bound Pt-methionine Intermediates, J. Inorg. Biochem., 1995, 2-3, 151. 1994

67. Z.J. Guo, G. Faraglia and S. Sitran, Palladium and Platinum Dihalide Complexes with L-Methioninol, Polyhedron, 1994, 13, 659-665.

68. Z.J. Guo, U. Casellato, G. Faraglia, R. Graziani and S. Sitran, Platinum(II) and Palladium(II) Complexes with 2-amino-4-methylsulfanyl-Butanol and 2-(ethylsulfanyl)ethylamine, J. Chem. Soc., Dalton Trans., 1994, 3231-3235. 1993

69. D. Fregona, Z.J. Guo, G. Faraglia and S. Sitran, Organotin(IV) Complexes of 4-Pyrones, J. Coord. Chem., 1993, 28, 73-80.

70. Z.J. Guo, D. Fregona, G. Faraglia and S. Sitran, Palladium Dihalide Complexes with DL-Ethionine, J. Coord. Chem., 1993, 28, 209-216.

71. Z.J. Guo, U. Casellato, G. Faraglia, R. Graziani and S. Sitran, A Study on the Palladium(II)-Methionine-2,6-Dimethyl-4H-Pyran-4-one System, J. Chem. Soc., Dalton Trans., 1993, 2509-2513. 1992

72. G. Faraglia, R. Graziani, Z.J. Guo and S. Sitran, Zinc and Cadmium Complexes with 2,4-dimethyl-4H-pyran-4-Thione, Inorg. Chim. Acta, 1992, 192, 17-23.

73. D. Fregona, Z.J. Guo, S. Sitran and G. Faraglia, Palladium and Platinum Dihalide Complexes with Carbonyl and Thiocarbonyl Donors, Transition Met. Chem., 1992, 17, 242-246. 1991

74. G. Faraglia, Z.J. Guo and S. Sitran, Mercury(II) Halide Complexes with Carbonyl and Thiocarbonyl Donors, Polyhedron, 1991, 10, 351-357.

75. G. Faraglia, D. Fregona, Z.J. Guo and S. Sitran, The Thermal Behaviour of Zinc and Cadmium Dihalide Complexes with O- and S- Donors, Thermochim. Acta, 1991, 191, 95-104.

76. Xue, Z.; Lin, M.; Zhu, J.; Zhang, J.; Li, Y.; Guo, Z.J.*, Platinum(II) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity, Chem. Commun., 2010, 46, 1212.

77. Liu, Z.; Zhang, C.; Li, Y.; Wu, Z.; Qian, F.; Yang, Z.; He, W.J.*; Gao, X.; Guo, Z.J.*, A Zn2+ Fluorescent Sensor Derived from 2-(Pyridin-2-yl)benzoimidazole with Ratiometric Sensing Potential, Org. Lett., 2009, 11, 795-798.

78. Mao, J.F.; Zhang, Y.M.; Zhu, J.H.; Zhang, C.L.; Guo, Z.J.* , Molecular combo of photodynamic therapeutic agent silicon(IV) phthalocyanine and anticancer drug cisplatin, Chem. Commun., 2009, 908.

79. Qian, F.; Zhang,C.L.; Zhang, Y.M.; He, W.J.*; Gao, X.; Hu, P.; Guo, Z.J.*, Visible Light Excitable Zn2+ Fluorescent Sensor Derived from an Intramolecular Charge Transfer Fluorophore and Its in Vitro and in Vivo Application, J. Am. Chem. Soc., 2009, 131, 1460.

讲授课程

Bioinorgnaic Chemistry

科研项目

国家自然科学基金重点项目：“金属人工核酸酶的设计与构筑”

国家自然科学基金创新群体项目：“功能配位化合物”

江苏省自然科学基金创新攀登项目：“生物功能金属配合物”

2000.1-2003.12，主持项目“金属药物的设计与作用机理研究”

2003.01-2006.12，主持国家自然科学基金重点项目“金属、生物大分子与DNA相互作用的化学基础”

2004.01-2006.12，主持国家自然科学基金项目“生物锌离子荧光探针的设计与构筑”

新闻报导

郭子建院士为金陵学院师生作专题讲座

省侨联领导来校看望陈洪渊院士和郭子建院士